Research Fund Secretariat - Detail of Approved Project (Reference No.: 11121721)

Detail of Approved Project (Reference No.: 11121721)

Fund	:	HMRF - Health and Health Services (including HHSRF)
Project Status	:	Closed
Reference No.	:	11121721
Project Title	:	Treatment resistance following the first-episode schizophrenia-spectrum disorder: a retospective case-control study
Research Activity Code	:	Aetiology
Health Category	:	Mental health
Applicant(s)	:	Chan KW(1) Chen EYH(1) Chang WC(1) Lee EHM(1) Wong GHY(1) Hui CLM(1) Sham PC(2)
Affiliation(s)	:	Department of Psychiatry, The University of Hong Kong(1) Queen Mary Hospital(2)
Approved Amount (HK$)	:	$799,952.00
Abstract	:	Purpose This study will evaluate the patterns of development of treatment resistance after the first-episode of schizophrenia-spectrum disorder and identify the predictive factors. The functional outcomes of patients treated with clozapine will explored. Hypothesis Treatment resistant patients with schizophrenia following the initial onset have younger age of onset and poorer premorbid functioning than control patients. Patients who develop treatment-resistant at later stages have longer DUP, increase number of relapse and higher average dose of antipsychotic medication before the start of clozapine than control patients. Design and subjects This is a retrospective case-control study. The sample will be chosen from a cohort of first-episode patients (n=1400) with duration of illness more than 10 years. The presciption of clozpine will be used as proxy for treatment resistance status (estimated to be 140). The treatment resistant status will be further verified based on standard criteria. Control patients are those who were not prescibed with clozapine and are non-treatment resistant at the assessment point. Study instruments Information will be collected through structured interview with the participants and by reviewing their case notes and hospital electronic records using standardized assessment scales. Main measures and analysis The main predictors assessed are age, premorbid functioning, DUP, number of relapse and average dose of antipsychotic medication. The main outcomes are social and occupation functioning. Dependent t-test and Wilcoxon signed-rank will be used for between group comparisons. Binary logistic regression and Cox regression will be used to explore the predictors.
Keywords	:	Schizophrenia;Treatment-resistant;predictors
Instruments	:
Remarks	:

Dissemination Report	:
Final Report	:		11121721fr.pdf

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